Smith Group

Synthetic Medicinal Chemistry

The Group


Welcome to the Smith Group.  Our main interest lies within the area of synthetic medicinal chemistry.  We are interested in developing molecules for healthcare applications, from antimicrobial chemotherapy to developing dyes for imaging/staining purposes - we do some really colourful chemistry!   

Electrochemically initiated release: exploring new modalities for controlled drug release


A. Devine, C. Hegarty, C. Casimero, R.L. Molyneaux, R.B. Smith, M.F. Cardosi, J. Davis

Journal of Electroanalytical Chemistry, vol. 872, 2020


N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections


C.L. Lawrence, A.O. Okoh, V. Vishwapathi, S.T. McKenna, M.E. Critchley, R.B. Smith

Bioorganic Chemistry, vol. 102, 2020


Electroanalytical properties of chlorophenol red at disposable carbon electrodes: Implications for Escherichia coli detection


C. Casimero, T. Bigham, R.J. McGlynn, J.S.G. Dooley, N.G. Ternan, W.J. Snelling, M.E. Critchley, C.L. Zinkel, R.B. Smith, L.P. Sabogal-Paz, J. Davis

Bioelectrochemistry, vol. 130, 2019


Microneedle array sensors based on carbon nanoparticle composites: interfacial chemistry and electroanalytical properties


C. Hegarty, S. McKillop, R.J. McGlynn, R.B. Smith, A. Mathur, J. Davis

Journal of Materials Science, vol. 54, 2019, pp. 10705-10714


1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections


M. Jalab, M.E. Critchley, C.M. Taylor, C.L. Lawrence, R.B. Smith

Bioorganic Chemistry, vol. 91, 2019


Design of a smart sensor mesh for the measurement of pH in ostomy applications


A. McLister, C. Casimero, A. McConville, C.M. Taylor, C.L. Lawrence, R.B. Smith, A. Mathur, J. Davis

Journal of Materials Science, vol. 54, 2019, pp. 10410-10419


Synthesis and photophysical properties of meso-aminophenyl-substituted heptamethine dyes as potential leads to new contrast agents


O.A. Okoh, M.E. Critchley, R.H. Bisby, C.L. Lawrence, M. Wainwright, R.B. Smith

Coloration Technology, vol. 135, 2019, pp. 305-311


Sensor systems for bacterial reactors: A new flavin-phenol composite film for the in situ voltammetric measurement of pH


C. Casimero, A. McConville, J.-J. Fearon, C.L. Lawrence, C.M. Taylor, R.B. Smith, J. Davis

Analytica Chimica Acta, vol. 1027, 2018, pp. 1-8


Disposable solid state pH sensor based on flavin polymer-ferrocyanide redox couples


C. Hegarty, S. Kirkwood, M.F. Cardosi, C.L. Lawrence, C.M. Taylor, R.B. Smith, J. Davis

Microchemical Journal, vol. 139, 2018, pp. 210-215


Photoactive plants: Botany bad boys or horticultural heroes?


M. Wainwright, W.J. Stockburn, C.L. Lawrence, H.J. Stevens, A.E. Jones, R.B. Smith

Phytotherapy Research, vol. 32, 2018, pp. 561-563


A rapid, chromatography-free route to substituted acridine-isoalloxazine conjugates under microwave irradiation


S.C. Johns, L.L.E. Crouch, S. Grieve, H.L. Maloney, G.R. Peczkowski, A.E. Jones, D. Sharp, R.B. Smith

Tetrahedron Letters, vol. 55, 2014, pp. 3308-3311


Promising near-infrared non-targeted probes: Benzothiazole heptamethine cyanine dyes


O.A. Okoh, R.H. Bisby, C.L. Lawrence, C.E. Rolph, R.B. Smith

Journal of Sulfur Chemistry, vol. 35, 2014, pp. 42-56


Smart bandages - A colourful approach to early stage infection detection & control in wound care


K.L. Brocklesby, S.C. Johns, A.E. Jones, D. Sharp, R.B. Smith

Medical Hypotheses, vol. 80, 2013, pp. 237-240


An interdisciplinary experiment: Azodye metabolism by Staphylococcus aureus


K. Brocklesby, R. Smith, D. Sharp

Journal of Biological Education, vol. 46, 2012, pp. 247-251


Synthesis of ethyl nalidixate: A medicinal chemistry experiment


R. Leslie, E. Leeb, R.B. Smith

Journal of Chemical Education, vol. 89, 2012, pp. 144-146


Limitations of the Jacobs-Gould reaction using microwave irradiation


R.B. Smith, H. Faki, R. Leslie

Synthetic Communications, vol. 41, 2011, pp. 1492-1499


Approaching intelligent infection diagnostics: Carbon fibre sensor for electrochemical pyocyanin detection


D. Sharp, P. Gladstone, R.B. Smith, S. Forsythe, J. Davis

Bioelectrochemistry, vol. 77, 2010, pp. 114-119


Epoxide-quinone transformations: Multi-parametric indicators for assessing animal welfare


L. Lee, M.M. Villalba, R.B. Smith, J. Davis

Electrochemistry Communications, vol. 11, 2009, pp. 1555-1558


Covert approaches to countering adult chemophobia


S. Billington, R.B. Smith, N.G. Karousos, E. Cowham, J. Davis

Journal of Chemical Education, vol. 85, 2008, pp. 379-380


Bromide-sulfur interchange: Ion chromatographic determination of total reduced thiol levels in plasma


S.A. Chitre, G.-A.M. Lobo, S.M. Rathod, R.B. Smith, R. Leslie, C. Livingstone, J. Davis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 864, 2008, pp. 173-177


Synthesis of acridine-quinone systems - A potential electrochemical fluorescent switch


V.J. Litchfield, R.B. Smith, A.M. Franklin, J. Davis

Synthetic Communications, vol. 38, 2008, pp. 3447-3455


Rapid assessment of the latent hazard posed by dissolved mercaptans within aqueous effluent


M.M. Villalba, V.J. Litchfield, R.B. Smith, A.M. Franklin, N.S. Lawrence, J. Davis

Journal of Hazardous Materials, vol. 154, 2008, pp. 444-450


Electrochemical characterisation of novel water-soluble ruthenocene complexes: An anion-dependent response


N.S. Lawrence, C.E. Banks, G.J. Tustin, T.G.J. Jones, R.B. Smith, J. Davis, J.D. Wadhawan

Electrochemistry Communications, vol. 9, 2007, pp. 1451-1455


Determination of total reduced thiol levels in plasma using a bromide substituted quinone


G.-A.M. Lobo, S.A. Chitre, S.M. Rathod, R.B. Smith, R. Leslie, C. Livingstone, J. Davis

Electroanalysis, vol. 19, 2007, pp. 2523-2528


Synthesis and characterisation of water soluble ferrocenes: Molecular tuning of redox potentials


G.J. Tustin, V.G.H. Lafitte, C.E. Banks, T.G.J. Jones, R.B. Smith, J. Davis, N.S. Lawrence

Journal of Organometallic Chemistry, vol. 692, 2007, pp. 5173-5182


A chromatographic tool for preparing combinatorial quinone-thiol conjugate libraries


M.M. Villalba, V.J. Litchfield, R.B. Smith, A.M. Franklin, C. Livingstone, J. Davis

Journal of Biochemical and Biophysical Methods, vol. 70, 2007, pp. 797-802


Ephedrine-copper-carbon interactions: An electroanalytical investigation


M. Platts, R.B. Smith, N. Mould, J. Davis

Electrochemistry Communications, vol. 8, 2006, pp. 633-637


Molecular anchors - Mimicking metabolic processes in thiol analysis


R.B. Smith, C. Canton, N.S. Lawrence, C. Livingstone, J. Davis

New Journal of Chemistry, vol. 30, 2006, pp. 1718-1724


Metabolic mimics: Thiol responsive drug release


I.A. Solsona, R.B. Smith, C. Livingstone, J. Davis

Journal of Colloid and Interface Science, vol. 302, 2006, pp. 698-701

Pages


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Dr Robert B Smith



School of Engineering & Computing

University of Central Lancashire

Dr Rob Smith
JBF 203
JB Firth Building
School of Engineering & Computing
University of Central Lancashire
Preston
PR1 2HE


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